Research & News

Use of Tenofovir for PrEP in Women in Africa

Apr 16, 2015

A randomized, controlled trial that was part of the VOICE study compared oral tenofovir, tenofovir-emtricitabine combo, and tenofovir vaginal gel in efficacy for preexposure prophylaxis in African women.  During the trial, adherence to medication regimen was low and... Read More

What Influences a Detectable Viral Load at Delivery?

Apr 16, 2015

Pregnant women who initiated HAART (highly active antiretroviral therapy) during pregnancy do not always achieve an undetectable viral load prior to delivery.  This cohort study looked at the frequency with which women had a detectable viral load at delivery and the... Read More

ARV Exposure In Utero and Congenital Anomaly Risk

Apr 16, 2015

Researchers in the Pediatric HIV/AIDS Cohort Study's Surveillance Monitoring of ART Toxicities (SMARTT) project found overall a low absolute risk of congenital anomalies resulting from in utero exposure to ARVs.  This shows an ongoing benefit of continuing to use ARVs for... Read More

Characteristics of Patients Undergoing Preconception Counseling

Apr 16, 2015

Couples who are both HIV sero-concordant and sero-discordant utilize preconception counseling to achieve pregnancy.  This study looked at the characteristics and issues of those seeking preconception counseling.  HIV-positive women (whether single or part of a couple)... Read More

AZT and Heart Defects in Children

Apr 16, 2015

Researchers from the French Perinatal Cohort study examined exposure to zidovudine (AZT) in utero and occurrence of congenital heart defects in those children who are HIV-negative.  Among the study population, exposure to AZT during the first trimester of pregnancy was... Read More

Ethical Issues Around Pregnancy and HIV

Apr 16, 2015

Authors address the ethical concerns around HIV-testing and treatment in pregnant women through a case study discussion and a review of state laws for perinatal and newborn testing.  Clinicians should make sure they are aware of the laws and best practices in their... Read More

Decline in Perinatal HIV Transmission Rates 2000-2011

Apr 03, 2015

From 2000-2011, perinatal HIV transmission rates have continually declined in the United Kingdom and Ireland, reaching a low of 5 per 1,000 in 2010-2011. Earlier initiation of ART during pregnancy contributed to this decrease. Rates of transmission were lower in women... Read More

Factors Contributing to High Rates of Perinatal HIV Transmission

Apr 01, 2015

Perinatal HIV has yet to be eliminated in the United States due to a number of factors.  Researchers did a chart review to determine what factors contribute to higher rates of transmission.  As might be expected, lack of prenatal care and limited to no use of... Read More

Updated Pediatric Guidelines Available - March 2015

Mar 05, 2015

The US Public Health Service released an update to the Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection on March 5, 2015.  This update can be found on the AIDSInfo site and on our website under the USPHS Perinatal Guidelines Quick Link.

Raltegravir and Pregnancy

Jan 30, 2015

Researchers looked at the pharmacokinetics of raltegravir for use as an antiretroviral during pregnancy.  Despite decreased rates of absorption during pregnancy, the drug readily crossed the placenta.  Similar decreases in rates in non pregnant adults indicates that... Read More

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