Syphilis Treatment Guidelines

Treatment of syphilis in pregnancy is complex and accurate staging of syphilis is essential to adequate treatment. The Perinatal Syphilis Warmline is available to assist with interpretation of test results, staging of infection and recommendations for treatment. Pregnant people must be treated with benzathine penicillin G (Bicillin®L-A) according to the stage of infection. Sex partners must be treated to avoid reinfection in the pregnant person.

Resources for treatment guidelines for syphilis include the following: 

Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines, 2021

Centers for Disease Control and Prevention STI Treatment Guidelines - Provider Resources, 2021

IDPH Syphilis Staging and Treatment Algorithm for Illinois, 2018