Cost-Effectiveness of Directly Observed Therapy for Perinatal HIV Prevention

Researchers used mathematical modeling to analyze the effect of women on self-administered HAART versus HAART using directly observed therapy (DOT) versus no HAART on quality of life of their infants. DOT was overall highly cost-effective in reducing mother-to-child transmission. Especially targeting those women with high viral loads to participate in DOT would save costs. Modeling has shown that further analysis through clinical trials is warranted.

Citation:
McCabe CJ, Goldie SU, Fisman DN. The cost-effectiveness of directly observed highly-active antiretroviral therapy in the third trimester in HIV-infected pregnant women. PLoS One. 2010 April 13;5(4)e10154.

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Abstract