HAART and Adverse Birth Outcomes in Botswana

Researchers found that use of HAART for HIV control during pregnancy was associated with higher rates of adverse birth outcomes than the use of AZT alone. Women on HAART had higher rates of preterm delivery (PTD), small for gestational age births (SGAs), and stillbirth. Additionally, low CD4 counts were associated with stillbirth and SGA. Commenters caution that the results are not necessarily generalizable to the US as the HAART regimen used in the study is not used in the US.

Chen JY, Ribaudo HJ, Souda S, Parekh N, Ogwu A, Lockman S, Powis K, Dryden-Peterson S, Creek T, Jimbo W, Madidimalo T, Makhema J, Essex M, Shapiro RL. Highly active antiretroviral therapy and adverse birth outcomes among HIV-infected women in Botswana. J Infect Dis. 2012 Dec;206(11):1695-705.

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