Data Support Nevirapine for Presumptive Treatment in High Risk Neonates
Recent findings from the IMPAACT P1115 study confirm the safety and therapeutic drug concentrations of a nevirapine-based antiretroviral regimen in the early neonatal period. The study's aim was to establish dosing of nevirapine for very early treatment of HIV-exposed neonates at high risk of HIV acquisition.
Citation: Ruel TD et al. Pharmacokinetics and safety of early nevirapine-based antiretroviral therapy for neonates at high risk for perinatal HIV infection: a phase 1/2 proof of concept study. Lancet HIV. 2020 Nov 23;S2352-3018(20)30274-5.
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