Benefits and Risks of ART for Perinatal HIV Prevention

The authors present randomized-trial data on the risks and benefits of ART as compared to zidovudine and single-dose nevirapine for prevention of HIV transmission from mother to child. Antenatal ART resulted in significantly lower rates of early HIV transmission but a higher risk of adverse maternal and neonatal outcomes.


Fowler MG et al for the IMPAACT 1077BF/1077FF PROMISE Study Team. Benefits and risks of antiretroviral therapy for perinatal HIV prevention. N Engl J Med 2016; 375:1726-1737.

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