Preterm Delivery Among Women on ARVs

Researchers looked retrospectively at delivery records from HIV-positive women who delivered between 1996 and 2010 to determine if use of ARVs during pregnancy contributed to preterm delivery.  These results showed some correlation between the use of ARVs and the incidence of preterm delivery with those women who initiated combination therapy during pregnancy at higher risk of preterm delivery than those on monotherapy or who were on therapy prior to conception.  Looking at timing of administration and type of maternal ARVs prescribed is necessary to better understand the relationship between maternal ARV use and preterm delivery.


Short CE, Douglas M, Smith JH, Taylor GP. Preterm delivery risk in women initiating antiretroviral therapy to prevent HIV mother-to-child transmission. HIV Med. 2014 Apr;15(4):233-8.