Lopinavir/Ritonavir and Dosing During Pregnancy
Although recommended as the preferred protease inhibitor for antiretroviral therapy during pregnancy, optimal dosing for Lopinavir/Ritonavir has not been provided in the guidelines. This study looked at providing an increased dose (3 tablets daily versus two) during the third trimester to provide the best protection against vertical transmission. At the increased dose, absorption was similar to that of nonpregnant patients receiving the standard dosing. Lower concentrations during pregnancy may be due to absorption differences caused by the pregnancy.
Citation:
Best BM, Stek AM, Mirochnick M, Hu C, Li H, Burchett SK, Rossi SS, Smith E, Read JS, Capparelli EV; international Maternal Pediatric Adolescent AIDS Clinical Trials Group 1026s Study Team. J Acquir Immune Defic Syndr. 2010 Aug 1;54(4):381-8.
Original Article (Subscription may be required)
Abstract
Citation:
Best BM, Stek AM, Mirochnick M, Hu C, Li H, Burchett SK, Rossi SS, Smith E, Read JS, Capparelli EV; international Maternal Pediatric Adolescent AIDS Clinical Trials Group 1026s Study Team. J Acquir Immune Defic Syndr. 2010 Aug 1;54(4):381-8.
Original Article (Subscription may be required)
Abstract
