AZT and Heart Defects in Children
Researchers from the French Perinatal Cohort study examined exposure to zidovudine (AZT) in utero and occurrence of congenital heart defects in those children who are HIV-negative. Among the study population, exposure to AZT during the first trimester of pregnancy was significantly associated with congenital heart disease, specifically ventricular septal defects. Researchers urge further review of the long term implications of AZT exposure on cardiac function in these children.
Citation: Sibiude J, Le Chenadec J, Bonnet D, Tubiana R, Faye A, Dollfus C, Mandlebrot L, Delmas S, Lelong N, Khoshnood B, Warszawski J, Blanche S; ANRS-French Perinatal Cohort/Primeva trial. In utero exposure to zidovudine and heart anomalies in the ANRS-EPF French Perinatal Cohort and the nested PRIMEVA randomized trial. Clin Infect Dis. 2015 Apr 1. pii: civ260. [Epub ahead of print]
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