ART for Infants with Exposure to Nevirapine In Utero

For those infants that were exposed to a single dose of nevirapine (NVP) given to the mother for prevention of HIV transmission, infant antiretrovital therapy consisting of zidovudine (AZT), lamivudine (3TC), plus NVP was less effective than ART consisting of AZT, 3TC, and Kaletra. This is possibly due to prior exposure in utero to NVP. Use of NVP for both treatment and prevention of HIV in resource limited settings needs to be reviewed due to this data.

Palumbo P, Lindsey JC, Hughes MD, Cotton MF, Bobat R, Meyers T, Bwakura-Dangarembizi M, Chi BH, Musoke P, Kamthunzi P, Schimana W, Purdue L, Eshleman SH, Abrams EJ, Millar L, Petzold E, Mofenson LM, Jean-Philippe P, Violari A. Antiretroviral treatment for children with peripartum nevirapine exposure. N Engl J Med. 2010 Oct 14;363(16):1510-20.

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